| kB |
receptor binding rate |
0.058 |
min-1 |
Simpson, 1980 |
6243359 |
mouse |
in vitro NMJ |
35-36 |
~7.2 |
|
| kT |
translocation rate |
0.141 |
min-1 |
Simpson, 1980 |
6243359 |
mouse |
in vitro NMJ |
35-36 |
~7.2 |
|
| kL |
lytic (toxic) rate |
0.013 |
min-1 |
Simpson, 1980 |
6243359 |
mouse |
in vitro NMJ |
35-36 |
~7.2 |
|
| kS |
bulk solution to receptor rate |
≥0.01 |
min-1 |
Lebeda et al., 2008 |
|
mouse |
in vitro NMJ |
35-36 |
~7.2 |
Simpson, 1980 (PMID: 6243359) |
| kS |
bulk solution to receptor rate |
0.001 |
min-1 |
Lebeda et al., 2008 |
18551355 |
mouse |
in vivo i.m. injection |
|
|
raw data from
Aoki, 2002 (PMID: 12076646)
and Keller, 2006 (PMID: 16490322) |
| kS |
bulk solution to receptor rate |
0.00015 |
min-1 |
Lebeda et al., 2008 |
18551355 |
human |
in vivo i.m. injection |
|
|
raw data from
Dressler and Adib Saberi, 2005 (PMID: 15650306) |
| kON |
association rate of BoNT/A
to its binding sites |
0.0138 |
nM-1 min-1 |
Dolly et al., 1982 |
7043781 |
mouse |
brain synaptosomes |
4 |
|
|
| kOFF |
dissociation rate of BoNT/A
from its binding sites |
0.0072 |
min-1 |
Dolly et al., 1982 |
7043781 |
mouse |
brain synaptosomes |
4 |
|
|
| kON |
association rate of BoNT/A
to its binding sites |
0.056 |
nM-1 min-1 |
Lebeda et al., 2008 |
18551355 |
mouse |
brain synaptosomes |
35 |
|
|
| kOFF |
dissociation rate of BoNT/A
from its binding sites |
0.029 |
min-1 |
Lebeda et al., 2008 |
18551355 |
mouse |
brain synaptosomes |
35 |
|
|
|
