Experimental data concerning the onset of paralysis of skeletal muscles induced by BoNT/A at the isolated rat neuromuscular junction (NMJ) and in other systems from several laboratories were simulated with two different kinetics minimalist models: 3-Step Model and 4-Step Model (Lebeda, Adler, Erickson, & Chushak (2008). Requires PDF Reader. Download PDF).
Model simulations require Java Web Start. If you do not have it installed in your system, you may download it from Sun Microsystems, Inc.. If you encounter any problem in launching these models, please contact us at botdb[AT]mail.nih.gov.