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IC50-to-Ki converter (Enzyme-Substrate-Inhibitor System)

Please use the default enzyme concentration [E], substrate concentration [S], Michaelis-Menten constant Km, and IC50 to convert to Ki value or enter your own values.


COMPLEX AND POTENTIALLY COOPERATIVE INHIBITOR EXAMPLE (CYP3A4) -Ref Marechal JD et al. 2006
Enzyme concentration, [E] All units in µM
Substrate concentration, [S]  
Michaelis-Menten constant, Km  
Inhibitor concentration to
produce 50% inhibition, IC50
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OTHER EXAMPLES
(1) Classic inhibitor (botulinum neurotoxin type A) - Ref Burnett et al. 2007
(2) Tight-binding inhibitor (monoamine oxidase A) - Ref Fowler CJ and Strolin BM 1983

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Last updated on December 30 2008


Sponsored by U. S. Army Medical Research Institute of Infectious Diseases (USAMRIID) in collaboration with the National Cancer Institute (NCI) and Advanced Biomedical Computing Center (ABCC).Support for this project was provided by the Defense Threat Reduction Agency Joint Science and Technology Office-Chemical Biological defense (DTRA JSTO-CBD) project 3.10043_07_RD_B and by the National Cancer Institute, National Institutes of Health, under contract No. HHSN261200800001E. a logo of the U.S. Army Medical Research Institute of Infectious Disease a logo of the National Cancer Institute, United States a logo of the Advanced Biomedical Computing Center, Advanced Technology Program
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